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HPR Retinoid

HPR Retinoid (HPR (Hydroxypinacolone retinoate))

INCI: Hydroxypinacolone Retinoate

Newer form of vitamin A for fine lines

Moderate evidence: clinical studies

At a glance

Suits
Normal, dry and mature skin

What can HPR Retinoid help with?

Fine lines

In two studies, lines and wrinkles became less visible with serums combining HPR with peptides and another form of vitamin A, respectively. The studies lasted 16 and 8 weeks.[1][2]

Skin elasticity

In an 8-week study of 42 women, skin elasticity improved with a serum containing HPR and retinyl propionate.[2]

Read our guide to HPR Retinoid

How it works

HPR is a form of vitamin A made from retinoic acid, the active form of vitamin A. On the ingredient list, it is called hydroxypinacolone retinoate.

HPR is used in skincare targeting fine lines and other visible signs of ageing. In a laboratory study of cosmetic products, HPR was the most stable of the vitamin A forms examined.[3]

How to use it

  • Start with 2–3 times a week unless the product instructions say otherwise.
  • Use sunscreen during the day.
  • Avoid vitamin A products if you are pregnant or breastfeeding.

Products with HPR Retinoid

  • Firming Cream SPF 50

    Day cream with SPF 50 that gives visibly firmer skin in four weeks and protec...

    Fragrance-freeFragrance50 ml
  • Vitamin A Treatment

    Fragrance-free cream for fine lines and wrinkles that gives visibly smoother,...

    50 ml
See all 2 products with HPR Retinoid

Frequently asked questions

Sources

The sources include two human studies in which HPR was investigated alongside other ingredients.[1][2] They also include a laboratory study of the stability of vitamin A forms in cosmetic products.[3]

  1. Efficacy of Topical Hydroxypinacolone Retinoate-Peptide Product Versus Fractional CO(2) Laser in Facial Aging (Journal of cosmetic dermatology, 2025)
  2. The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging (Journal of cosmetic dermatology, 2023)
  3. Retinoid stability and degradation kinetics in commercial cosmetic products (Journal of cosmetic dermatology, 2021)

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